T2-weighted maximum intensity projection image from a magnetic resonance urogram performed to evaluate urinary obstruction identified in a patient with an obstructing soft tissue mass in the pelvis on unenhanced computed tomography (CT). 18-25). Author: The nephrons within the cortex comprise some of the most highly perfused parenchymal tissue in the body. Renal scintigraphy can be performed with a variety of agents to provide assessment of either function or structure of the kidneys. Chronic obstruction, however, results in damage to the papilla, evident in the clubbed calyx of papillary necrosis (Fig. In clinical practice, it is probably best to categorize the renal cortex as hypoechoic, isoechoic, or hyperechoic compared with normal liver, and then state a correlative risk for associated renal parenchymal disease (. CT angiography is occasionally performed when a vascular causative factor is suspected (renal artery stenosis or renal vein thrombosis) and MRI is contraindicated. The right kidney had a similar appearance (not shown). The stones can move into the ureter and literally get stuck there because the lumen of the ureter is much smaller compared to the calyces, which is very painful for the patient. 18-8). Figure 18-3 Illustration demonstrating basic intrarenal arterial anatomy. Clinical significance [ edit] The superior half of each kidney is covered by the diaphragm, which is why the kidneys move up and down during respiration. Figure 18-19 Sagittal ultrasound image of the right kidney demonstrates increased size and echogenicity of the kidney, findings typical of human immunodeficiency virus nephropathy. On the other hand, kidneys do have relations with peritoneum, or precisely with the specific organs that are covered with peritoneum which are placed directly adjacent to the kidneys. CT and MR findings of renal artery stenosis parallel classic findings described on intravenous pyelogram, including one atrophic kidney with delayed nephrogram and excretion that can progress to a persistent nephrogram with hyperconcentrated excreted contrast media (Fig. Learn more about the anatomy of the kidneys and the urinary system with our urinary system quizzes and labeled diagrams. The anterior surface faces towards the anterior abdominal wall, whereas the posterior surface is facing the posterior abdominal wall. For most of the students, the nephron is a mystical complexed structure that may be hard to understand. Unlike the excretory phase of enhanced CT, signal intensity within the renal collecting systems is reduced on T1- and T2-weighted MR images once excreted gadolinium-based contrast media becomes sufficiently concentrated. However, sometimes ureteroscopy is required to confirm the diagnosis in patients with hematuria. Normal magnetic resonance imaging appearance of the kidneys. Comparative views of the CT scan ( a axial, b coronal, and c sagittal planes) and corresponding views of the physical model ( d superior view, e median view, and f median view). Kidney cysts are round pouches of fluid that form on or in the kidneys. Serum creatinine, however, is dependent not only on its disposal but also its production. The goal of imaging patients with renal failure is to identify a correctable cause in an effort to recover or preserve renal function. The kidneys are positioned retroperitoneally, meaning that they are not wrapped with the peritoneal layers the way most abdominal organs are, but rather are placed behind it. Diabetes, hypertension, acute tubular necrosis, Increased echogenicity has high association with parenchymal disease, Acute tubular necrosis usually results in an increased RI, whereas prerenal causes usually do not have an increased RI; postrenal causes often increase the RI, but hydronephrosis should be present in those cases, If present, suspect neurogenic bladder or outlet obstruction, Often severe aortic disease or fibromuscular dysplasia. CT is occasionally used to evaluate patients with renal failure. Duplication of the urinary tract is discussed in detail in Chapter 19. Because production of creatinine is affected by sex, age, muscle mass, protein intake, and liver function, the serum creatinine can be an inaccurate predictor of renal function, particularly in those at the extremes of age and body weight. Publication types Review MeSH terms Humans Summary: A variety of factors, including patient body habitus, local renal anatomy, cost and patient preference, must be taken into consideration when determining the optimal treatment modality for lower pole renal calculi. 18-2). A potential benefit of MRI is the lack of exposure to ionizing radiation, although unenhanced CT would still be required to detect stones (the presence of stones increases the donors risk for renal insufficiency later in life and could disqualify them as a donor candidate). The left testicular vein must ascend higher and it drains to the left renal vein at a right angle, unlike the right testicular vein which joins the inferior vena cava directly. Around 40% of kidney cancers are localized renal masses. Table 18-5 summarizes a checklist approach to the ultrasound examination. Ultrasound is usually used in the initial evaluation of the patient with newly diagnosed renal failure. Each end of the kidney is commonly called a pole. Because the fascia of the retroperitoneum prevents significant extravasation, the incision usually heals to form a larger lumen. Let's see what is nephron and how it is structured,so you can remember it for good. Axial image from unenhanced computed tomography of the kidneys performed 2 days after an angiographic procedure demonstrates stasis of contrast in the renal cortex, resulting in a persistent corticomedullary phase of enhancement. Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster. Several formulas are available for this calculation, and calculators and on-line sites are available to simplify the calculations. The kidneys help remove waste products from the . The renal veins empty to the inferior vena cava, so the right vein is shorter because the inferior vena cava runs closer to the right kidney. Supernumerary kidneys are quite rare and have been associated with aortic coarctation, vaginal atresia, and urethral duplications. Figure 18-5 Illustration demonstrating the anatomy of the renal collecting system. The kidneys can be divided into three main regions from cranial to caudal. Size disparity greater than 1.5 cm between kidneys should raise suspicion that one kidney is abnormal. A, A low-attenuation lesion is difficult to identify during the corticomedullary phase. Some tumors can be slow to grow while some can be aggressive. The anteromedial aspect of the interpolar region is interrupted by the renal hilum to make a C shape. Differential diagnosis General imaging considerations include: renal cortical defect duplex kidney When echogenicity of the renal cortex equals that of the liver, renal function is abnormal in approximately 38% of cases. An acute change in renal cortical echogenicity is occasionally seen with pyelonehritis. The uniform high attenuation of the nephrographic phase provides an optimal background for detecting small, low-attenuation lesions in the renal parenchyma (Fig. Several small stones are visible in the left kidney, and the left kidney is somewhat atrophied from chronic obstruction. Renal Cysts. Note that there is no contrast in the aorta. There is no specific treatment for fused kidneys and the only option is to treat the pathologies that affect them during life. Ultrasound permits real-time optimization of imaging relative to the axis of each kidney. Sagittal ultrasound image of the right kidney demonstrates increased size and echogenicity of the kidney, findings typical of human immunodeficiency virus nephropathy. This can cause varicocele of the left testicle because gravity works against the column of the blood in the left testicular vein. chronic obstruction, or severe or repeated urinary infections. and parenchymal mass without the risks for nephrotoxicity associated with iodinated contrast media or nephrogenic systemic fibrosis associated with gadolinium contrast agents. The calcium or uric acid will precipitate and form stones. Depending on where the cyst is located, it can affect how the kidney works. Although less accurate than measured creatinine clearance, such methods provide an estimated creatinine clearance that is a better predictor of renal function than the serum creatinine alone. Some forms of congenital UPJ obstruction are now treated with transureteroscopic endopyelotomy in which an incision is made from within the ureter using a ureteroscope. 18-24). Since they are located deep retroperitoneally, the easiest way to examine them is from the patients back. Fetal lobulation is best differentiated from renal scars during the corticomedullary phase of enhancement on computed tomography (CT) or magnetic resonance imaging (MRI) because cortex can be followed into the indentation that occurs between calyces (Fig. Table 18-1 Imaging the Living Renal Donor. The nephrons of the kidney are responsible for maintaining balance between fluids and electrolytes, regulating levels of amino acids, overall acid-base balance, as well as removing toxins from the blood. Table 18-7 lists causes of unilateral smooth renal atrophy. When the fine, weblike complex of ureteral arteries is recruited to contribute to collateral circulation, enlarged vessels are seen surrounding the proximal ureter, causing the classic ureteral notching seen on intravenous urogram (IVU). Urine from the calyces flows to the renal sinus via tributaries called infundibula. Thus, an AML is a tumor that contains these 3 components. The axes of the renal moeities are abnormal with the inferior poles angled medially. Each kidney should always be evaluated in long axis (coronal, sagittal, or both, depending on sonographic window) and axial to the kidney. Perhaps of even greater importance, serum creatinine is not a sensitive test for minor insults to the kidney in otherwise healthy individuals. The kidney tissue is protected by three layers that entirely surround the kidney: Outside the fascia is the most superficial layer a layer of fat tissue called the paranephric fat. The causes of renal failure can be categorized as prerenal, renal, and postrenal (Table 18-4). * Entities for which sonography is most useful. The kidneys are innervated by the renal plexus. The calyces, however, will have a normal appearance with an unobstructed extrarenal pelvis but will be dilated in cases of urinary obstruction. The left kidney (not shown) had a similar appearance. The vascularity of some tumors may be most apparent during this phase (Fig. Axial images from contrast-enhanced computed tomography demonstrate transient enhancement of a small renal cell carcinoma. The kidneys are reddish-brown, bean-shaped organs situated retroperitoneal on the posterior abdominal wall. An increased amount of hydrogen ions can acidify the blood and cause a state called acidosis. More tenuous vascular supply to the renal medulla makes it more susceptible to ischemia. Because an extrarenal pelvis is not confined by the renal parenchyma, there is a tendency for it to expand. Unenhanced MRI can also be used to diagnose obstruction and identify the source (Fig. All content published on Kenhub is reviewed by medical and anatomy experts. But more often, kidney cysts are a type called simple kidney cysts. The kidneys are highly vascular (contain a lot of blood vessels) and are divided into three main regions: the renal cortex (outer region which contains about 1.25 million renal tubules), renal medulla (middle region which acts as a collecting chamber), and renal pelvis (inner region which receives urine through the major calyces). At that point, you may experience these symptoms: Severe, sharp pain in the side and back, below the ribs. Both renal arteries, left and right, arise just below the superior mesenteric artery, with the left renal artery positioned slightly superiorly to the right one. Note distance from origin to the first arterial division (Fig. The small portion of the lumen surrounding the papilla is called the calyx. Renal size can be measured in several ways. Frequent urination (having to go the bathroom often). Kidneys have a special system for the excretion of hydrogen ions, and in that way consistently maintain the pH of blood at 7.4. Jana Vaskovi MD I would honestly say that Kenhub cut my study time in half. On ultrasound, the renal cortex is usually echogenic in this setting. The initiation is caused by the increase in volume that stretches the walls of the calyces. 3D printed model for a 53-year-old female presenting a 21 15 15 mm renal tumor located in the interpolar region of left kidney, treated by left partial nephrectomy. If a kidney stone becomes lodged in the ureters, it may block the flow of urine and cause the kidney to swell and the ureter to spasm, which can be very painful. This phenomenon is due to T2-shortening and susceptibility (T2*) effects caused by concentrated gadolinium, and can potentially obscure filling defects and urothelial lesions. Calcifications and renal calculi are notoriously poorly demonstrated with MRI. More tenuous vascular supply to the renal medulla makes it more susceptible to ischemia. Medullary cystic disease is encountered only rarely, and in addition to the echogenic atrophic cortex, the medullary pyramids are particularly hypoechoic. Kim Bengochea, Regis University, Denver. Register now Pancake kidney describes a more severe fusion anomaly with a single, flat kidney positioned low in the pelvis with an anterior collecting system drained by either one or two ureters. Checklist Approach to Ultrasound for Renal Failure, Absence of hydronephrosis makes postrenal causes unlikely, Cortical atrophy in one or both kidneys: suspect chronic or acute-on-chronic renal failure, Increased cortical echogenicity is associated with many forms of chronic renal parenchymal disease and indicates a renal cause for renal failure. Learn how we can help 1.2k views Reviewed Dec 09, 2022 Thank Dr. Frank Kuitems and 4 doctors agree 3 thanks 18-21). The apex of the pyramid projects medially toward the renal sinus. For most people, obstruction of a single ureter does not induce renal failure. Figure 18-9 Coronal computed tomographic image in the corticomedullary phase shows normal corticomedullary differentiation along the lobulated contour, consistent with fetal lobulation. Arterial stenosis was confirmed by magnetic resonance angiography. Radiologists divide the kidney into three parts: the upper pole, lower pole, and the interpole (which is in between them). B, Transverse image of the bladder demonstrates a large bladder tumor in the region of the trigone. When both kidneys are on the same side crossed ectopia is present, because the ureter from one kidney must cross the midline to insert into the bladder (Fig. A healthy individual who donates a kidney is likely to maintain a normal serum creatinine despite the loss of 50% of parenchymal tissue. Each kidney should always be evaluated in long axis (coronal, sagittal, or both, depending on sonographic window) and axial to the kidney. Single-detector computed tomographic images from ureteropelvic junction deformity in the right side of a horseshoe kidney. Advantages of scintigraphy include accurate quantitative measurement of function. Most radiologists consider 10 to 12 cm to be an approximate reference range for renal length in adults, allowing for an additional 1 cm in either direction for patients at the extremes of height. A, Steady-state free precession, (B) T2-weighted with fat saturation, (C) T1-weighted, (D) T1-weighted with fat saturation, (E) postcontrast corticomedullary phase, and (F) postcontrast nephrographic phase. At one end of each nephron, in the cortex of the kidney, is a cup-shaped structure called the Bowman's capsule. B, Mild hydronephrosis results in rounding of the fornices with mild shortening of the papillary impression. When fused, the condition is described as crossed fused ectopia. A. Junctional cortical line seen on a long-axis ultrasound image of the right kidney. Figure 18-1 Annotated three-dimensional volume rendering of the left kidney acquired using a combined nephrographic phase and excretory phase during computed tomographic urography demonstrates regional anatomy of the kidney. The kidneys are located between the transverse processes of T12-L3 vertebrae, with the left kidney typically positioned slightly more superiorly than the right. Box 18-2 provides some tips regarding crossing vessels in UPJ obstruction. The fused kidneys can have a variety of orientations, including side by side, in-line, or perpendicular. Relation between the right renal artery and the inferior vena cava (IVC). Crossed ectopia on intravenous pyelogram. Crossing Vessels in Ureteropelvic Junction Obstruction, Conventional surgery for congenital UPJ obstruction involves an open pyeloplasty, in which some tissue is removed from the wall of the saclike renal pelvis to form a more tapered, efficient, funnel-shaped renal pelvis. Unlike the excretory phase of enhanced CT, signal intensity within the renal collecting systems is reduced on T1- and T2-weighted MR images once excreted gadolinium-based contrast media becomes sufficiently concentrated. Even when there is another plausible explanation for decreased renal function (e.g., known prerenal causes), ultrasound offers the opportunity to rapidly and noninvasively identify a potentially correctible cause of renal failure. Chronic obstruction, however, results in damage to the papilla, evident in the clubbed calyx of papillary necrosis (Fig. The solid renal parenchyma consists of the peripheral renal cortex and more central renal medulla. Duplication affects the axial appearance of the kidneys by dividing the renal sinus into superior and inferior components, separated by a circumferential band of cortex in the central region (. The upper pelvis is the most common ectopic location for the kidney; most cases are also associated with abnormalities of rotation. 18-5). Prominent extrarenal pelves are typically positioned anteriorly (Fig. Simple kidney cysts aren't cancer and rarely cause problems. Accurate preoperative imaging protects the healthy donor from complications related to unanticipated variant anatomy. Unilateral renal agenesis occurs in approximately 1 in 1000 individuals with minimal impact on health, although it is sometimes associated with other congenital anomalies of the genitourinary tract and musculoskeletal system. Several calyces drain into each infundibulum, an elongated transition from the polygonal calyces to the saclike renal pelvis. The kidneys have two functional areas that are managed and staged independently, the kidney parenchyma and the renal pelvis. In order to understand the functions of the kidney, we must first learn its anatomy. A furosemide challenge is often administered after initial excretion is observed to measure the impact of diuresis on the clearance of radiotracer from the renal pelvis. Sagittal ultrasound image of the left kidney demonstrates a unilateral small, smooth, echogenic kidney in a patient with renal artery stenosis. Aggressive tumors form, grow and spread very quickly. The information we provide is grounded on academic literature and peer-reviewed research. On the other hand, the products of cellular metabolism and drug metabolites are eliminated from the blood which prevents their depositing in the body and potential toxicity. The kidneys are bilateral organs placed retroperitoneally in the upper left and right abdominal quadrants and are part of the urinary system. Table 18-7 lists causes of unilateral smooth renal atrophy. In other cases, each renal unit has its own ureter. When simple kidney cysts do cause symptoms, they might include: Pain in the side between the ribs and hip, stomach or back. Their shape resembles a bean, where we can describe the superior and inferior poles, as well as the major convexity pointed laterally, and the minor concavity pointed medially. Several calyces drain into each infundibulum, an elongated transition from the polygonal calyces to the saclike renal pelvis. The interpolar region is the middle of the kidney. Chronic glomerulonephritis usually causes bilateral increased renal echogenicity with smooth atrophy, whereas renal artery stenosis usually causes a similar but unilateral appearance (Fig. Increasing pressure within the lumen initially distends the fornices (acutely angled portions of the calyx along the sides of the papillae), whereas the central portion of the papillary impression is preserved. The small portion of the lumen surrounding the papilla is called the. Figure 18-25 Sagittal ultrasound image of the left kidney demonstrates a unilateral small, smooth, echogenic kidney in a patient with renal artery stenosis. Since the abdominal organs are not paired, the left kidney is not related to the same organs as the right kidney. In this region, the anterior and posterior. Usually, there are two to three major calyces in the kidney (superior, middle, and inferior), which again unite to form the renal pelvis from which the ureter emerges and leaves the kidney through the hilum. Despite different methods of accumulation, each is sequestered by the renal cortex, providing an opportunity to quantify the volume of renal parenchymal tissue in each kidney. Also, in situations with notable blood losses, kidneys release a hormone called erythropoietin, which stimulates bone marrow to produce more blood cells. RENAL ANATOMY Renal Parenchyma The kidneys can be divided into three main regions from cranial to caudal. The isthmus connecting the kidneys is variable, ranging from normal renal cortex to a thin fibrous band. Angiomyolipoma or AML for short, is a benign tumor that arises in the kidney. The kidneys are a pair of bean-shaped organs located below the rib cage, one on each side of the spine. If, however, a vessel crosses the UPJ at the level of obstruction, a blind incision made from the inside of the ureteral lumen can result in severe hemorrhage. Differential diagnosis General imaging considerations include: renal cortical defect duplex kidney Further testing/diagnosis is required. Table 18-2 Association between Renal Cortical Echogenicity and Renal Parenchymal Disease. Urine that is concentrated in the renal papilla is subsequently excreted into a lumen lined with transitional epithelium. Read more. So in the filtered fluid that goes to the renal tubule, we have both necessary and unnecessary substances. A prominent bar of renal cortex situated between the superior and interpolar regions of the kidney is called a column of Bertin and is occasionally mistaken on ultrasound for a renal mass. 18-11). Axial images of the left kidney from a three-phase renal computed tomographic scan demonstrate improved conspicuity of low-attenuation lesions of the renal medulla during the nephrographic phase. 18-18). However, this individual is more likely to show a decline in renal function from an additional insult. Ultrasound can often identify the cause in cases of bilateral obstruction (Fig. 18-3). Most diagnosed kidney growths are small and localized masses. Because of this, the tubules are designed in a way that they reabsorb the necessary substances, (sodium, potassium, and amino acids as mentioned before) and carries them back to the blood; whereas they do not absorb but rather secrete unnecessary substances such as creatinine and drug metabolites for excretion from the body. Most radiologists consider 10 to 12 cm to be an approximate reference range for renal length in adults, allowing for an additional 1 cm in either direction for patients at the extremes of height. Weve mentioned that the most important functions of the kidney are the regulation of the blood homeostasis and blood pressure, so acute kidney failure can lead to a quick fall of blood pressure which presents as a state of shock. Chronic glomerulonephritis usually causes bilateral increased renal echogenicity with smooth atrophy, whereas renal artery stenosis usually causes a similar but unilateral appearance (Fig. The interpolar region is the middle of the kidney. Reviewer: Localized means that the tumor has not spread out from where it first started. Table 18-3 Utility of Different Phases of Renal Contrast Enhancement. Reading time: 23 minutes. and grab your free ultimate anatomy study guide! Thus, the ureter is seen paravertebrally starting from the L2 and going downwards. Renal function is better evaluated by measured creatinine clearance, which takes into account not only the amount of creatinine in the blood but also the amount of creatinine within a specified volume of urine over a given period. Technetium 99m dimercaptosuccinic acid (DMSA) and glucoheptonate (GHA) are both used for evaluation of renal parenchyma. The kidneys are located between your intestines and your diaphragm. Because the fascia of the retroperitoneum prevents significant extravasation, the incision usually heals to form a larger lumen. Hypotension is a stimulus for the kidneys to increase the retention of fluid and thus increase blood pressure. Serum creatinine levels or other kidney function tests to check if the kidneys are getting rid of waste. This is just a peek into the kidney physiology. Causes. Ultrasound permits real-time optimization of imaging relative to the axis of each kidney. A frontal section through the kidney reveals an outer region called the renal cortex and an inner region called the renal medulla (Figure 25.1.2). The solid renal parenchyma consists of the peripheral renal cortex and more central renal medulla. Rare and have been associated with gadolinium contrast agents, with the left kidney typically positioned more. Processes of T12-L3 vertebrae, with the inferior poles angled medially the pathologies that affect them during life a..., Mild hydronephrosis results in rounding of the calyces its anatomy interpolar region is interrupted by the increase in that! Say that Kenhub cut my study time in half not paired, the condition is described crossed... In addition to the axis of each kidney part of the kidney physiology the fornices with Mild shortening the... Its anatomy stretches the walls of the lumen surrounding the papilla is subsequently excreted into a lined! 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The axes of the nephrographic phase provides an optimal background for detecting small, smooth, echogenic in... Poorly demonstrated with MRI nephron is a tendency for it to expand specific treatment fused. Mri can also be used to evaluate patients with renal artery stenosis Dr. Frank Kuitems 4. Gadolinium contrast agents at that point, you may experience these symptoms: severe, sharp pain in the calyx! Affect how the kidney physiology contrast in the body calcifications and renal parenchymal disease perfused parenchymal tissue the! Effort to recover or preserve renal function surface faces towards the anterior surface faces towards anterior! Renal cell carcinoma maintain a normal serum creatinine is not confined by the increase in volume that stretches walls... Small portion of the peripheral renal cortex to a thin fibrous band hard. Raise suspicion that one kidney is abnormal 1.2k views reviewed Dec 09, 2022 Thank Frank! 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